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ACAM2000 uses a live mild virus strain in the same family as monkeypox and smallpox that can still spread in the human body and to other people. The CDC generally recommends Jynneos over ACAM2000, which can have serious side effects. Tecovirimat was the first pill approved by the FDA in 2018 to treat smallpox, though it can also be used against monkeypox under a CDC program. is also distributing an oral antiviral called tecovirimat that can be used to treat people infected with monkeypox, Panjabi said. Monkeypox is in the same virus family as smallpox, though it is much milder. Though ACAM2000 was approved by the FDA in 2007 to prevent smallpox, the vaccine can also be used to protect against monkeypox under a CDC program. Raj Panjabi, who leads the White House pandemic preparedness office, in a call with reporters Friday. has distributed 1,200 doses of Jynneos and ACAM2000 for people who have high-risk exposures to monkeypox, said Dr. ACAM2000 is made by Emergent BioSolutions also has more than 100 million doses of the older-generation smallpox vaccine ACAM2000, the spokesperson said.

The two-dose vaccine is the only shot approved to specifically prevent monkeypox. The Food and Drug Administration approved Jynneos for adults ages 18 and older at high risk of smallpox or monkeypox in 2019. Most of the cases are in Europe, particularly in Portugal, Spain and the United Kingdom. Nearly 800 confirmed cases of monkeypox across 27 countries have been reported to the World Health Organization. The global monkeypox outbreak is the largest ever outside of Africa. and can fill 16.4 million more doses upon request by the federal government, the spokesperson said. Bavarian Nordic is holding more than 1 million doses owned by the U.S. told Bavarian Nordic, a Danish biotech company, to ship an additional 36,000 doses of Jynneos in the near future, said Dawn O'Co​nnell, HHS assistant secretary for preparedness and response.